Article
Genetic mutation in Escherichia coli genome during adaptation to the murine intestine is optimized for the host diet.
mSystems - 20 Feb 2024
Tsukimi Tomoya, Obana Nozomu, Shigemori Suguru, Arakawa Kazuharu, Miyauchi Eiji, Yang Jiayue, Song Isaiah, Ashino Yujin, Wakayama Masataka, Soga Tomoyoshi, Tomita Masaru, Ohno Hiroshi, Mori Hirotada, Fukuda Shinji
Abstract excerpt
Mammalian gut microbes colonize the intestinal tract of their host and adapt to establish a microbial ecosystem. The host diet changes the nutrient profile of the intestine and has a high impact on microbiota composition. Genetic mutations in Escherichia coli, a prevalent species in the human gut, allow for adaptation to the mammalian intestine, as reported in previous studies. However, the extent of colonization...
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