Article
Comparative whole-genome sequence analysis of Mycobacterium tuberculosis isolated from tuberculous meningitis and pulmonary tuberculosis patients.
Scientific reports - 20 Mar 2018
Faksri Kiatichai, Xia Eryu, Ong Rick Twee-Hee, Tan Jun Hao, Nonghanphithak Ditthawat, Makhao Nampueng, Thamnongdee Nongnard, Thanormchat Arirat, Phurattanakornkul Arisa, Rattanarangsee Somcharn, Ratanajaraya Chate, Suriyaphol Prapat, Prammananan Therdsak, Teo Yik-Ying, Chaiprasert Angkana
Abstract excerpt
Tuberculous meningitis (TBM) is a severe form of tuberculosis with a high mortality rate. The factors associated with TBM pathogenesis are still unclear. Using comparative whole-genome sequence analysis we compared Mycobacterium tuberculosis (Mtb) isolates from cerebrospinal fluid of TBM cases (n = 73) with those from sputum of pulmonary tuberculosis (PulTB) patients (n = 220) from Thailand. The aim of this study...
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