Article
Association between fatty acid metabolism gene mutations and Mycobacterium tuberculosis transmission revealed by whole genome sequencing.
BMC microbiology - 1 Dec 2023
Li Yameng, Kong Xianglong, Li Yifan, Tao Ningning, Wang Tingting, Li Yingying, Hou Yawei, Zhu Xuehan, Han Qilin, Zhang Yuzhen, An Qiqi, Liu Yao, Li Huaichen
Abstract excerpt
BACKGROUND: Fatty acid metabolism greatly promotes the virulence and pathogenicity of Mycobacterium tuberculosis (M.tb). However, the regulatory mechanism of fatty acid metabolism in M.tb remains to be elucidated, and limited evidence about the effects of gene mutations in fatty acid metabolism on the transmission of M.tb was reported. RESULTS: Overall, a total of 3193 M.tb isolates were included in the study, of...
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