Transcriptional expression of PHR2 is positively controlled by the calcium signaling transcription factor Crz1 through its binding motif in the promoter

Abstract excerpt

ABSTRACT GH72 family of β-(1,3)-glucanosyltransferases is required for cell wall biogenesis, morphogenesis, and virulence of fungi. Candida albicans PHR2 is an acidic pH-induced gene that encodes a GH72 enzyme involved in cross-linking of β−1,3- and β−1,6-glucans in the cell wall. In response to environmental pH changes, the expression of PHR2 is negatively regulated by the transcription factor CaRim101 through...

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