Article
RIM101-dependent and-independent pathways govern pH responses in Candida albicans.
Molecular and cellular biology - 1 Feb 2000
Davis D, Wilson R B, Mitchell A P
Abstract excerpt
Growth and differentiation of Candida albicans over a broad pH range underlie its ability to infect an array of tissues in susceptible hosts. We identified C. albicans RIM101, RIM20, and RIM8 based on their homology to components of the one known fungal pH response pathway. PCR product-disruption mutations in each gene cause defects in three responses to alkaline pH: filamentation, induction of PRA1 and PHR1, and...
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