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Article

Dominant active alleles of RIM101 (PRR2) bypass the pH restriction on filamentation of Candida albicans.

Molecular and cellular biology - 1 Jul 2000

El Barkani A, Kurzai O, Fonzi W A, Ramon A, Porta A, Frosch M, Mühlschlegel F A

Abstract excerpt

Morphological development of the fungal pathogen Candida albicans is profoundly affected by ambient pH. Acidic pH restricts growth to the yeast form, whereas neutral pH permits development of the filamentous form. Superimposed on the pH restriction is a temperature requirement of approximately 37 degrees C for filamentation. The role of pH in development was investigated by selecting revertants of phr2Delta...

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Identifiers

PMID: 10848590
DOI: 10.1128/MCB.20.13.4635-4647.2000
PMCID: PMC85869

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Dominant active alleles of RIM101 (PRR2) bypass the pH restriction on filamentation of Candida albicans.PMID 10848590Read ↗

RIM101-dependent and-independent pathways govern pH responses in Candida albicans.Semantic proximity Read ↗

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PHR2 of Candida albicans encodes a functional homolog of the pH-regulated gene PHR1 with an inverted pattern of pH-dependent expression.Semantic proximity Read ↗

PRR1, a homolog of Aspergillus nidulans palF, controls pH-dependent gene expression and filamentation in Candida albicans.Semantic proximity Read ↗

Evidence for novel pH-dependent regulation of Candida albicans Rim101, a direct transcriptional repressor of the cell wall beta-glycosidase Phr2.Semantic proximity Read ↗

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PHR1, a pH-regulated gene of Candida albicans encoding a glucan-remodelling enzyme, is required for adhesion and invasion.Semantic proximity Read ↗

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Malassezia responds to environmental pH signals through the conserved Rim/Pal pathwaySemantic proximity Read ↗

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