Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA methylation–mediated Rbpjk suppression protects against fracture nonunion caused by systemic inflammation

5 Dec 2023

Abstract excerpt

Challenging skeletal repairs are frequently seen in patients experiencing systemic inflammation. To tackle the complexity and heterogeneity of the skeletal repair process, we performed single-cell RNA sequencing and revealed that progenitor cells were one of the major lineages responsive to elevated inflammation and this response adversely affected progenitor differentiation by upregulation of Rbpjk in fracture...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Immune cells in cancer
Share to Neonatal Respiratory Health Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38051594
DOI: 10.1172/jci168558

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA methylation–mediated Rbpjk suppression protects against fracture nonunion caused by systemic inflammationPMID 38051594Read ↗

Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development.Semantic proximity Read ↗

Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cellsSemantic proximity Read ↗

Interferon-gamma signaling promotes cartilage regeneration after injurySemantic proximity Read ↗

Mouse Homolog of Human IRF8 <sup>G388S</sup> Mutation Provides Novel Insight into Osteoclastogenesis and Tooth Root ResorptionSemantic proximity Read ↗

Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone developmentSemantic proximity Read ↗

A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation.Semantic proximity Read ↗

NAIL: an evolutionarily conserved lncRNA essential for licensing coordinated activation of p38 and NFκB in colitisSemantic proximity Read ↗

<i>Dnmt3a</i> mutations limit normal and autoreactive Tfh differentiationSemantic proximity Read ↗

Systemic NF-κB-mediated inflammation promotes an aging phenotype in skeletal stem/progenitor cells.Semantic proximity Read ↗

MHC Class II Transactivator Is an In Vivo Regulator of Osteoclast Differentiation and Bone Homeostasis Co-opted From Adaptive ImmunitySemantic proximity Read ↗

RBPJ mediates uterine repair in the mouse and is reduced in women with recurrent pregnancy lossSemantic proximity Read ↗

Myeloid Krüppel-Like Factor 2 Critically Regulates K/BxN Serum-Induced ArthritisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.