Article
Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development.
PloS one - 1 Jan 2014
Swarnkar Gaurav, Zhang Kaihua, Mbalaviele Gabriel, Long Fanxin, Abu-Amer Yousef
Abstract excerpt
Pathologic conditions impair bone homeostasis. The transcription factor NF-κB regulates bone homeostasis and is central to bone pathologies. Whereas contribution of NF-κB to heightened osteoclast activity is well-documented, the mechanisms underlying NF-κB impact on chondrocytes and osteoblasts are scarce. In this study, we examined the effect of constitutively active IKK2 (IKK2ca) on chondrogenic and osteogenic...
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