RBPJ mediates uterine repair in the mouse and is reduced in women with recurrent pregnancy loss

Abstract excerpt

Unexplained recurrent pregnancy loss (uRPL) is associated with repeated embryo loss and endometrial repair with elevated endometrial expression of inflammatory cytokines, including IFN‐γ. Notch signaling through its transcription factor recombination signal binding protein Jk (RBPJ) regulates mechanisms including the immune response and repair after tissue injury. Initially, null mutation of RBPJ in the mouse...

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