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DNA Methylation Drives Aberrant Osteochondrogenesis in Keloid and Is Reversible by Decitabine

2026-08-31

Abstract excerpt

Keloids are benign fibroproliferative disorders majorly characterized by excessive extracellular matrix deposition, with recurrence rates exceeding 80% following conventional therapy. Although epigenetic dysregulation has been implicated in keloid pathogenesis, whether genome-wide DNA methylation actively drives pathological cellular reprogramming, and whether this state is therapeutically reversible, remains uncl...

Identifiers and source

Literature Corpus work
95755c98-cee6-59b7-9f55-53184bee12ec
DOI
10.64898/2026.08.26.747276
Open publication

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DNA Methylation Drives Aberrant Osteochondrogenesis in Keloid and Is Reversible by DecitabineDOI 10.64898/2026.08.26.747276
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