Article

Mouse Homolog of Human IRF8 <sup>G388S</sup> Mutation Provides Novel Insight into Osteoclastogenesis and Tooth Root Resorption

2023-04-23

Abstract excerpt

<h4>ABSTRACT</h4> Previously, we reported a novel mutation in the Interferon Regulatory Factor 8 ( IRF8 ) gene associated with multiple idiopathic cervical root resorption (MICRR), an aggressive form of tooth root resorption mediated by increased osteoclast activity. The IRF8 G388S variant in the highly conserved C-terminal motif is predicted to alter the protein structure, likely impairing IRF8 function. To inv...

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Literature Corpus work: 6dec7cba-7563-583b-bb49-8cfb2e938f9f
DOI: 10.1101/2023.04.23.537931

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Mouse Homolog of Human IRF8 <sup>G388S</sup> Mutation Provides Novel Insight into Osteoclastogenesis and Tooth Root ResorptionDOI 10.1101/2023.04.23.537931Read

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