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A population modification gene drive targeting both Saglin and Lipophorin impairs Plasmodium transmission in Anopheles mosquitoes

5 Dec 2023

Abstract excerpt

Lipophorin is an essential, highly expressed lipid transport protein that is secreted and circulates in insect hemolymph. We hijacked the Anopheles coluzzii Lipophorin gene to make it co-express a single-chain version of antibody 2A10, which binds sporozoites of the malaria parasite Plasmodium falciparum . The resulting transgenic mosquitoes show a markedly decreased ability to transmit Plasmodium berghei...

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PMID: 38051195
DOI: 10.7554/elife.93142

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