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Gene drive mosquitoes can aid malaria elimination by retarding Plasmodium sporogonic development

21 Sept 2022

Abstract excerpt

Gene drives hold promise for the genetic control of malaria vectors. The development of vector population modification strategies hinges on the availability of effector mechanisms impeding parasite development in transgenic mosquitoes. We augmented a midgut gene of the malaria mosquito Anopheles gambiae to secrete two exogenous antimicrobial peptides, magainin 2 and melittin. This small genetic modification,...

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PMID: 36129981
DOI: 10.1126/sciadv.abo1733

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