Article

Gene Drive Mosquitoes Can Aid Malaria Elimination by Retarding Plasmodium Sporogonic Development

2022-02-17

Abstract excerpt

Gene drives hold promise for the genetic control of malaria vectors. The development of vector population modification strategies hinges on the availability of effector mechanisms impeding parasite development in transgenic mosquitoes. We augmented a midgut gene of the malaria mosquito Anopheles gambiae to secrete two exogenous antimicrobial peptides, Magainin 2 and Melittin. This small genetic modification, capa...

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Identifiers and source

Literature Corpus work: 6be1e315-9967-5fce-b18f-8a40270f8ecb
DOI: 10.1101/2022.02.15.480588

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