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A multiplexed, confinable CRISPR/Cas9 gene drive can propagate in caged Aedes aegypti populations

25 Jan 2024

Abstract excerpt

Aedes aegypti is the main vector of several major pathogens including dengue, Zika and chikungunya viruses. Classical mosquito control strategies utilizing insecticides are threatened by rising resistance. This has stimulated interest in new genetic systems such as gene drivesHere, we test the regulatory sequences from the Ae. aegypti benign gonial cell neoplasm (bgcn) homolog to express Cas9 and a separate...

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PMID: 38272895
DOI: 10.1038/s41467-024-44956-2

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