Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease.

BMC medicine - 5 Dec 2023

Yang Fangkun, Xu Fengzhe, Zhang Han, Gill Dipender, Larsson Susanna C, Li Xue, Cui Hanbin, Yuan Shuai

Abstract excerpt

BACKGROUND: We aimed to investigate the protein pathways linking obesity and lifestyle factors to coronary artery disease (CAD). METHODS: Summary-level genome-wide association statistics of CAD were obtained from the CARDIoGRAMplusC4D consortium (60,801 cases and 123,504 controls) and the FinnGen study (R8, 39,036 cases and 303,463 controls). Proteome-wide Mendelian randomization (MR) analysis was conducted to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules
Share to Coronary Artery Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Life Style

Share to Mendelian Randomization Analysis

Share to Obesity

Share to Proprotein Convertase 9

Share to Proteomics

Share to Receptor Protein-Tyrosine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 38049831
DOI: 10.1186/s12916-023-03197-8
PMCID: PMC10696760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease.PMID 38049831Read ↗

Discovery and Validation of Molecular Biomarkers Contributing to the Risk of Coronary Artery DiseaseSemantic proximity Read ↗

Discovery and validation of molecular biomarkers contributing to the risk of coronary artery disease.Semantic proximity Read ↗

Plasma Proteomic Profiles Predict the Risk of Coronary Artery Disease in the UK Biobank CohortSemantic proximity Read ↗

Integrative proteogenomic analysis identifies COL6A3-derived endotrophin as a mediator of the effect of obesity on coronary artery diseaseSemantic proximity Read ↗

Integrative genetic analysis reveals shared genetic architecture underlying coronary artery disease, CT-Defined coronary atherosclerosis, and cardiometabolic risk factors.Semantic proximity Read ↗

Therapeutic protein targets for cardiometabolic diseases: Mendelian randomization integrating plasma proteomes with genome-wide association dataSemantic proximity Read ↗

Epigenetic Regulation of ITGB7 Promotes Coronary Heart Disease via Immune and Metabolic Pathways: A Multimodal Mendelian Randomization Study.Semantic proximity Read ↗

Lifestyle factors, genetic susceptibility to obesity and their interactions on coronary artery disease risk: A cohort study in the UK Biobank.Semantic proximity Read ↗

Plasma proteins and onset of atherosclerosis: Integrating human plasma proteogenomics, transcriptomics and in vivo evidenceSemantic proximity Read ↗

Genetic associations of circulating plasma proteins with cardiometabolic diseases.Semantic proximity Read ↗

A framework for studying multi-omic risk factors and their interplay: application to coronary artery diseaseSemantic proximity Read ↗

Proteome-wide Mendelian randomization identifies candidate causal proteins for cardiovascular diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.