Lifestyle factors, genetic susceptibility to obesity and their interactions on coronary artery disease risk: A cohort study in the UK Biobank.

doi:10.1016/j.ypmed.2024.107886

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Article

Lifestyle factors, genetic susceptibility to obesity and their interactions on coronary artery disease risk: A cohort study in the UK Biobank.

Preventive medicine - 1 Mar 2024

Choi Jungyoon, Wen Wanqing, Jia Guochong, Tao Ran, Long Jirong, Shu Xiao-Ou, Zheng Wei

Abstract excerpt

OBJECTIVE: We aimed to evaluate potential modifying effects of genetic susceptibility to obesity on the association of lifestyle factors with coronary artery disease (CAD) risk. METHODS: A total of 328,606 participants (54% women) were included using data from the UK Biobank. We evaluated the risk of developing CAD associated with obesity-related polygenic scores (PGSs) and healthy lifestyle scores (HLSs). HLSs...

Topics

Humans
Female
Male
Coronary Artery Disease
Risk Factors
Cohort Studies
Genome-Wide Association Study
Biological Specimen Banks
UK Biobank
Obesity
Life Style
Genetic Predisposition to Disease

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PMID: 38316272
DOI: 10.1016/j.ypmed.2024.107886

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