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Article

Viral subversion of APOBEC3s: Lessons for anti-tumor immunity and tumor immunotherapy.

International reviews of immunology - 4 May 2018

Borzooee Faezeh, Asgharpour Mahdi, Quinlan Emma, Grant Michael D, Larijani Mani

Abstract excerpt

APOBEC3s (A3) are endogenous DNA-editing enzymes that are expressed in immune cells including T lymphocytes. A3s target and mutate the genomes of retroviruses that infect immune tissues such as the human immunodeficiency virus (HIV). Therefore, A3s were classically defined as host anti-viral innate immune factors. In contrast, we and others showed that A3s can also benefit the virus by mediating escape from...

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Identifiers

PMID: 29211501
DOI: 10.1080/08830185.2017.1403596

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