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APOBEC3B and APOBEC mutational signature as potential predictive markers for immunotherapy response in non-small cell lung cancer.

Oncogene - 1 Jul 2018

Wang Shixiang, Jia Mingming, He Zaoke, Liu Xue-Song

Abstract excerpt

Non-small cell lung cancer (NSCLC) is known to carry heavy mutation load. Besides smoking, cytidine deaminase APOBEC3B plays a key role in the mutation process of NSCLC. APOBEC3B is also reported to be upregulated and predicts bad prognosis in NSCLC. However, targeting APOBEC3B high NSCLC is still a big challenge. Here we show that APOBEC3B upregulation is significantly associated with immune gene expression, and...

Topics

APOBEC Deaminases
B7-H1 Antigen
Biomarkers, Tumor
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
Cytidine Deaminase
Gene Expression Regulation, Neoplastic
Humans
Immunotherapy
Lung Neoplasms
Minor Histocompatibility Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

T-Lymphocytes

Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 29695832
DOI: 10.1038/s41388-018-0245-9
PMCID: PMC6053356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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