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Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease

2 Dec 2023

Abstract excerpt

Abstract Background Memory CD8+ T cells expand with age. We previously demonstrated an age-associated expansion of effector memory (EM) CD8+ T cells expressing low levels of IL-7 receptor alpha (IL-7Rαlow) and the presence of its gene signature (i.e., IL-7Rαlow aging genes) in peripheral blood of older adults without Alzheimer’s disease (AD). Considering age as the strongest risk factor for AD and the recent...

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PMID: 38042785
DOI: 10.1186/s12979-023-00396-y

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