Article

“Altered CD8 <sup>+</sup> T cell associated aging gene signature in the peripheral blood of patients with Alzheimer’s disease”

2022-10-03

Abstract excerpt

<h4>INTRODUCTION</h4> Effector memory (EM) CD8 + T cells have been associated with poor cognition in Alzheimer’s disease (AD). Our lab recently discovered an age-associated gene expression signature of IL-7 receptor alpha (IL-7Rα) low EM CD8 + T cells. We hypothesized that individuals with AD have altered levels of this IL-7Rα low aging gene expression. <h4>METHODS</h4> Forty genes associated with IL-7Rα l...

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Literature Corpus work: 66b91176-7cf6-594e-8ed3-1ee3bf2ab318
DOI: 10.1101/2022.09.29.510171

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