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Identification of potential blood biomarkers for early diagnosis of Alzheimer’s disease through immune landscape analysis

4 Nov 2022

Abstract excerpt

Mild cognitive impairment (MCI) is a clinical precursor of Alzheimer's disease (AD). Recent genetic studies have reported on associations between AD risk genes and immunity. Here, we obtained samples and data from 317 AD, 432 MCI, and 107 cognitively normal (CN) subjects and investigated immune-cell type composition and immune clonal diversity of T-cell receptor (TRA, TRB, TRG, and TRD) and B-cell receptor (IGH,...

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PMID: 36333348
DOI: 10.1038/s41514-022-00096-9

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