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Article

Prevalence and outcomes of germline pathogenic variants of homologous recombination repair genes in ovarian cancer.

Cancer science - 1 Dec 2024

Miwa Maiko, Kitagawa Masakazu, Asami Yuka, Kobayashi-Kato Mayumi, Watanabe Takafumi, Ogasawara Aiko, Hiranuma Kengo, Kato Hisamori, Saito Motonobu, Miyagi Yohei, Kato Tomoyasu, Yoshida Hiroshi, Momozawa Yukihide, Kohno Takashi, Shiraishi Kouya, Hasegawa Kosei

Abstract excerpt

Germline pathogenic variants (PVs) are pivotal in gynecological oncology. We focused on the prevalence, clinicopathological features, and survival impact of homologous recombination repair (HRR) PVs in patients with epithelial ovarian cancer (EOC). This was a multicenter retrospective cohort study, and 1248 patients with EOC were registered. Eligible patients (n = 1112) underwent germline DNA analysis for 26...

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PMID: 39385713
DOI: 10.1111/cas.16367
PMCID: PMC11611769

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