Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas.

doi:10.1158/1078-0432.CCR-13-2287

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Article

Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2014

Pennington Kathryn P, Walsh Tom, Harrell Maria I, Lee Ming K, Pennil Christopher C, Rendi Mara H, Thornton Anne, Norquist Barbara M, Casadei Silvia, Nord Alexander S, Agnew Kathy J, Pritchard Colin C, Scroggins Sheena, Garcia Rochelle L, King Mary-Claire, Swisher Elizabeth M

Abstract excerpt

PURPOSE: Hallmarks of germline BRCA1/2-associated ovarian carcinomas include chemosensitivity and improved survival. The therapeutic impact of somatic BRCA1/2 mutations and mutations in other homologous recombination DNA repair genes is uncertain. EXPERIMENTAL DESIGN: Using targeted capture and massively parallel genomic sequencing, we assessed 390 ovarian carcinomas for germline and somatic loss-of-function...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24240112
DOI: 10.1158/1078-0432.CCR-13-2287
PMCID: PMC3944197

Genes

BRCA1
BRCA2
ATM
BARD1
BRIP1
CHEK1
CHEK2
NBN
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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