Article
Clinical characteristics of ovarian cancer classified by BRCA1, BRCA2, and RAD51C status.
Scientific reports - 7 Feb 2014
Cunningham J M, Cicek M S, Larson N B, Davila J, Wang C, Larson M C, Song H, Dicks E M, Harrington P, Wick M, Winterhoff B J, Hamidi H, Konecny G E, Chien J, Bibikova M, Fan J-B, Kalli K R, Lindor N M, Fridley B L, Pharoah P P D, Goode E L
Abstract excerpt
We evaluated homologous recombination deficient (HRD) phenotypes in epithelial ovarian cancer (EOC) considering BRCA1, BRCA2, and RAD51C in a large well-annotated patient set. We evaluated EOC patients for germline deleterious mutations (n = 899), somatic mutations (n = 279) and epigenetic alterations (n = 482) in these genes using NGS and genome-wide methylation arrays. Deleterious germline mutations were...
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