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Identifying potential genetic epistasis implicated in Alzheimer's disease via detection of SNP-SNP interaction on quantitative trait CSF Aβ42.

Neurobiology of aging - 1 Feb 2024

Li Jin, Chen Dandan, Liu Hongwei, Xi Yang, Luo Haoran, Wei Yiming, Liu Junfeng, Liang Hong, Zhang Qiushi

Abstract excerpt

Although genome-wide association studies have identified multiple Alzheimer's disease (AD)-associated loci by selecting the main effects of individual single-nucleotide polymorphisms (SNPs), the interpretation of genetic variance in AD is limited. Based on the linear regression method, we performed genome-wide SNP-SNP interaction on cerebrospinal fluid Aβ42 to identify potential genetic epistasis implicated in...

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PMID: 38039940
DOI: 10.1016/j.neurobiolaging.2023.10.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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