Article
Genome-wide association and interaction studies of CSF T-tau/Aβ42 ratio in ADNI cohort.
Neurobiology of aging - 1 Sept 2017
Li Jin, Zhang Qiushi, Chen Feng, Meng Xianglian, Liu Wenjie, Chen Dandan, Yan Jingwen, Kim Sungeun, Wang Lei, Feng Weixing, Saykin Andrew J, Liang Hong, Shen Li
Abstract excerpt
The pathogenic relevance in Alzheimer's disease (AD) presents a decrease of cerebrospinal fluid amyloid-ß42 (Aß42) burden and an increase in cerebrospinal fluid total tau (T-tau) levels. In this work, we performed genome-wide association study (GWAS) and genome-wide interaction study of T-tau/Aß42 ratio as an AD imaging quantitative trait on 843 subjects and 563,980 single-nucleotide polymorphisms (SNPs) in ADNI...
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