Article
Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels.
Alzheimer's research & therapy - 28 Aug 2018
Maxwell Taylor J, Corcoran Chris, Del-Aguila Jorge L, Budde John P, Deming Yuetiva, Cruchaga Carlos, Goate Alison M, Kauwe John S K
Abstract excerpt
BACKGROUND: A relationship quantitative trait locus exists when the correlation between multiple traits varies by genotype for that locus. Relationship quantitative trait loci (rQTL) are often involved in gene-by-gene (G×G) interactions or gene-by-environmental interactions, making them a powerful tool for detecting G×G. METHODS: We performed genome-wide association studies to identify rQTL between tau and Aβ42...
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