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Article

Identifying proteomic risk factors for cancer using prospective and exome analyses of 1463 circulating proteins and risk of 19 cancers in the UK Biobank.

Nature communications - 15 May 2024

Papier Keren, Atkins Joshua R, Tong Tammy Y N, Gaitskell Kezia, Desai Trishna, Ogamba Chibuzor F, Parsaeian Mahboubeh, Reeves Gillian K, Mills Ian G, Key Tim J, Smith-Byrne Karl, Travis Ruth C

Abstract excerpt

The availability of protein measurements and whole exome sequence data in the UK Biobank enables investigation of potential observational and genetic protein-cancer risk associations. We investigated associations of 1463 plasma proteins with incidence of 19 cancers and 9 cancer subsites in UK Biobank participants (average 12 years follow-up). Emerging protein-cancer associations were further explored using two...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 38750076
DOI: 10.1038/s41467-024-48017-6
PMCID: PMC11096312

Genes

ADAM8
CD74
SFTPA2
TNFRSF1B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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