Identifying proteomic risk factors for cancer using prospective and exome analyses of 1463 circulating proteins and risk of 19 cancers in the UK Biobank.

doi:10.1038/s41467-024-48017-6

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Article

Identifying proteomic risk factors for cancer using prospective and exome analyses of 1463 circulating proteins and risk of 19 cancers in the UK Biobank.

Nature communications - 15 May 2024

Papier Keren, Atkins Joshua R, Tong Tammy Y N, Gaitskell Kezia, Desai Trishna, Ogamba Chibuzor F, Parsaeian Mahboubeh, Reeves Gillian K, Mills Ian G, Key Tim J, Smith-Byrne Karl, Travis Ruth C

Abstract excerpt

The availability of protein measurements and whole exome sequence data in the UK Biobank enables investigation of potential observational and genetic protein-cancer risk associations. We investigated associations of 1463 plasma proteins with incidence of 19 cancers and 9 cancer subsites in UK Biobank participants (average 12 years follow-up). Emerging protein-cancer associations were further explored using two...

Topics

Humans
United Kingdom
Neoplasms
Risk Factors
Biological Specimen Banks
Male
Female
Exome
Proteomics
Prospective Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Blood Proteins

Aged

Exome Sequencing

Genetic Predisposition to Disease

Incidence

UK Biobank

Source

Open in PubMed Open full text

Identifiers

PMID: 38750076
DOI: 10.1038/s41467-024-48017-6
PMCID: PMC11096312

Genes

ADAM8
CD74
SFTPA2
TNFRSF1B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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