Article

ZNF687 couples bone marrow myeloid progenitor dynamics to osteoclastogenesis in severe Paget’s disease of bone

2026-08-12

Abstract excerpt

Paget’s disease of bone (PDB) is a late-onset skeletal disorder characterized by excessive osteoclast-mediated bone remodelling and disorganized bone deposition. The P937R mutation in the ZNF687 gene causes a severe form of PDB complicated by giant cell tumour transformation. Although ZNF687 has been implicated in osteoclastogenesis, whether it regulates upstream haematopoietic progenitor dynamics and bone marrow...

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Literature Corpus work: 07284531-8116-5804-a3cd-32ce18dad27f
DOI: 10.64898/2026.08.11.744220

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