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Article

The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis.

Arthritis research & therapy - 1 Jan 2004

Carrick Danielle M, Lai Wi S, Blackshear Perry J

Abstract excerpt

Tristetraprolin (TTP) is the best-studied member of a small family of three proteins in humans that is characterized by a tandem CCCH zinc finger (TZF) domain with highly conserved sequences and spacing. Although initially discovered as a gene that could be induced rapidly and transiently by the stimulation of fibroblasts with growth factors and mitogens, it is now known that TTP can bind to AU-rich elements in...

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Source

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Identifiers

PMID: 15535838
DOI: 10.1186/ar1441
PMCID: PMC1064869

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis.PMID 15535838Read ↗

Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stabilitySemantic proximity Read ↗

A Knock-In Tristetraprolin (TTP) Zinc Finger Point Mutation in Mice: Comparison with Complete TTP Deficiency.Semantic proximity Read ↗

Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies.Semantic proximity Read ↗

Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family.Semantic proximity Read ↗

Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs.Semantic proximity Read ↗

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Tristetraprolin expression by keratinocytes controls local and systemic inflammationSemantic proximity Read ↗

RNA sequence elements required for high affinity binding by the zinc finger domain of tristetraprolin: conformational changes coupled to the bipartite nature of Au-rich MRNA-destabilizing motifs.Semantic proximity Read ↗

Tristetraprolin (TTP) gene polymorphisms in patients with rheumatoid arthritis and healthy individuals.Semantic proximity Read ↗

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Gain-of-Function Mutation of Tristetraprolin Impairs Negative Feedback Control of Macrophages In Vitro yet Has Overwhelmingly Anti-Inflammatory Consequences In Vivo.Semantic proximity Read ↗

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