Article
Tristetraprolin Is Required for Alveolar Bone Homeostasis.
Journal of dental research - 1 Jul 2018
Steinkamp H M, Hathaway-Schrader J D, Chavez M B, Aartun J D, Zhang L, Jensen T, Shojaee Bakhtiari A, Helke K L, Stumpo D J, Alekseyenko A V, Novince C M, Blackshear P J, Kirkwood K L
Abstract excerpt
Tristetraprolin (TTP) is an RNA-binding protein that targets numerous immunomodulatory mRNA transcripts for degradation. Many TTP targets are key players in the pathogenesis of periodontal bone loss, including tumor necrosis factor-α. To better understand the extent that host immune factors play during periodontal bone loss, we assessed alveolar bone levels, inflammation and osteoclast activity in periodontal...
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