Article
Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data.
PLoS genetics - 9 Sept 2010
Bigham Abigail, Bauchet Marc, Pinto Dalila, Mao Xianyun, Akey Joshua M, Mei Rui, Scherer Stephen W, Julian Colleen G, Wilson Megan J, López Herráez David, Brutsaert Tom, Parra Esteban J, Moore Lorna G, Shriver Mark D
Abstract excerpt
High-altitude hypoxia (reduced inspired oxygen tension due to decreased barometric pressure) exerts severe physiological stress on the human body. Two high-altitude regions where humans have lived for millennia are the Andean Altiplano and the Tibetan Plateau. Populations living in these regions exhibit unique circulatory, respiratory, and hematological adaptations to life at high altitude. Although these...
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