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Article

Quantitative multi-parametric evaluation of centrosome declustering drugs: centrosome amplification, mitotic phenotype, cell cycle and death.

Cell death & disease - 1 May 2014

Ogden A, Cheng A, Rida P C G, Pannu V, Osan R, Clewley R, Aneja R

Abstract excerpt

Unlike normal cells, cancer cells contain amplified centrosomes and rely on centrosome clustering mechanisms to form a pseudobipolar spindle that circumvents potentially fatal spindle multipolarity (MP). Centrosome clustering also promotes low-grade chromosome missegregation, which can drive malignant transformation and tumor progression. Putative 'centrosome declustering drugs' represent a cancer cell-specific...

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Identifiers

PMID: 24787016
DOI: 10.1038/cddis.2014.164
PMCID: PMC4047924

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