Article
MSL2 ensures biallelic gene expression in mammals.
Nature - 1 Dec 2023
Sun Yidan, Wiese Meike, Hmadi Raed, Karayol Remzi, Seyfferth Janine, Martinez Greene Juan Alfonso, Erdogdu Niyazi Umut, Deboutte Ward, Arrigoni Laura, Holz Herbert, Renschler Gina, Hirsch Naama, Foertsch Arion, Basilicata Maria Felicia, Stehle Thomas, Shvedunova Maria, Bella Chiara, Pessoa Rodrigues Cecilia, Schwalb Bjoern, Cramer Patrick, Manke Thomas, Akhtar Asifa
Abstract excerpt
In diploid organisms, biallelic gene expression enables the production of adequate levels of mRNA1,2. This is essential for haploinsufficient genes, which require biallelic expression for optimal function to prevent the onset of developmental disorders1,3. Whether and how a biallelic or monoallelic state is determined in a cell-type-specific manner at individual loci remains unclear. MSL2 is known for dosage...
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