Article
Monoallelic gene expression in mammals.
Chromosoma - 1 Jun 2009
Zakharova Irina S, Shevchenko Alexander I, Zakian Suren M
Abstract excerpt
Three systems of monoallelic gene expression in mammals are known, namely, X-chromosome inactivation, imprinting, and allelic exclusion. In all three systems, monoallelic expression is regulated epigenetically and is frequently directed by long non-coding RNAs (ncRNAs). This review briefs all three systems of monoallelic gene expression in mammals focusing on chromatin modifications, spatial chromosome...
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