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Enhanced THBS2 promotes collagen synthesis and inflammatory secretome of fibroblasts in idiopathic pulmonary fibrosis

17 Jul 2025

Abstract excerpt

The pathogenesis of pulmonary fibrosis involves structural remodeling and functional impairment of lung tissue, accompanied by increased secretion of pro-inflammatory mediators and abnormal synthesis of the extracellular matrix (ECM). Thrombospondin-2 (THBS2), an ECM glycoprotein encoding gene, has been extensively studied in liver and heart fibrosis. However, its role in idiopathic pulmonary fibrosis (IPF) in...

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Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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PMID: 40676074
DOI: 10.1038/s41598-025-09318-y

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