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Molecular characterization and cell type composition deconvolution of fibrosis in NAFLD

10 Sept 2021

Abstract excerpt

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide. In adults with NAFLD, fibrosis can develop and progress to liver cirrhosis and liver failure. However, the underlying molecular mechanisms of fibrosis progression are not fully understood. Using total RNA-Seq, we investigated the molecular mechanisms of NAFLD and fibrosis. We sequenced liver tissue from 143 adults...

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PMID: 34508113
DOI: 10.1038/s41598-021-96966-5

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