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Detecting radio- and chemoresistant cells in 3D cancer co-cultures using chromatin biomarkers

24 Nov 2023

Abstract excerpt

The heterogenous treatment response of tumor cells limits the effectiveness of cancer therapy. While this heterogeneity has been linked to cell-to-cell variability within the complex tumor microenvironment, a quantitative biomarker that identifies and characterizes treatment-resistant cell populations is still missing. Herein, we use chromatin organization as a cost-efficient readout of the cells' states to...

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PMID: 38001169
DOI: 10.1038/s41598-023-47287-2

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