Article

Time-dependent chromatin maturation during 3D spheroid culture improves preclinical modeling of non-small cell lung cancer

2025-01-26

Abstract excerpt

<h4>ABSTRACT</h4> Non-small cell lung cancer (NSCLC) is the deadliest cancer worldwide. Therapeutic progress stagnate, highlighting the complexity to replicate NSCLC in preclinical models. Drug discovery studies rely mostly on cancer cells in two-dimension (2D), which poorly predict drug efficacy in patients. There is a growing interest in three-dimensional (3D) preclinical models, such as 3D spheroids, to better...

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Literature Corpus work: 836e01aa-f33d-54d8-ad4f-7e6469cc34af
DOI: 10.1101/2025.01.23.634518

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