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Article

Molecular dynamics of JUNO-IZUMO1 complexation suggests biologically relevant mechanisms in fertilization

20 Nov 2023

Abstract excerpt

Abstract JUNO-IZUMO1 binding is the first known physical link created between the sperm and egg membranes in fertilization, however, how this initiates sperm-egg fusion remains elusive. As advanced structural insights will help to combat the infertility crisis, or advance fertility control, we employed all-atom Molecular Dynamics (MD) to derive dynamic structural insights that are difficult to obtain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37990051
DOI: 10.1038/s41598-023-46835-0

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