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Article

Divergent evolution of vitamin B9 binding underlies Juno-mediated adhesion of mammalian gametes

1 Feb 2016

Abstract excerpt

The interaction between egg and sperm is the first necessary step of fertilization in all sexually reproducing organisms. A decade-long search for a protein pair mediating this event in mammals culminated in the identification of the glycosylphosphatidylinositol (GPI)-anchored glycoprotein Juno as the egg plasma membrane receptor of sperm Izumo1 [1,2]. The Juno-Izumo1 interaction was shown to be essential for...

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PMID: 26859261
DOI: 10.1016/j.cub.2015.12.034

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Divergent evolution of vitamin B9 binding underlies Juno-mediated adhesion of mammalian gametesPMID 26859261Read ↗

Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization.Semantic proximity Read ↗

Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization.Semantic proximity Read ↗

Genetic Diversity in the IZUMO1-JUNO Protein-Receptor Pair Involved in Human ReproductionSemantic proximity Read ↗

Sperm-Egg Fusion: A Molecular Enigma of Mammalian ReproductionSemantic proximity Read ↗

Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 accumulation in the intercellular contact area prior to fusion during mammalian fertilizationSemantic proximity Read ↗

Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complexSemantic proximity Read ↗

MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilizationSemantic proximity Read ↗

Allosteric inhibition of the IZUMO1–JUNO fertilization complex by the naturally occurring antisperm antibody OBF13Semantic proximity Read ↗

JUNO, the receptor of sperm IZUMO1, is expressed by the human oocyte and is essential for human fertilisationSemantic proximity Read ↗

IZUMO1 is a sperm fusogenSemantic proximity Read ↗

Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm–egg fusion in miceSemantic proximity Read ↗

Juno is the egg Izumo receptor and is essential for mammalian fertilizationSemantic proximity Read ↗

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