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Article

Allosteric inhibition of the IZUMO1–JUNO fertilization complex by the naturally occurring antisperm antibody OBF13

5 Mar 2025

Abstract excerpt

Sperm IZUMO1 binds to egg JUNO, and this interaction is essential for mammalian fertilization. Isolated from a female mouse immunized with syngeneic sperm, the antisperm antibody OBF13 recognizes IZUMO1 and inhibits murine fertilization. How OBF13 interferes with sperm-egg interactions was unknown. Here, we present the X-ray crystal structure of IZUMO1 in complex with OBF13. OBF13 binds to the apex of the...

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Identifiers

PMID: 40042902
DOI: 10.1073/pnas.2425952122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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