Article
Genomic profiling of subcutaneous patient-derived xenografts reveals immune constraints on tumor evolution in childhood solid cancer.
Nature communications - 22 Nov 2023
He Funan, Bandyopadhyay Abhik M, Klesse Laura J, Rogojina Anna, Chun Sang H, Butler Erin, Hartshorne Taylor, Holland Trevor, Garcia Dawn, Weldon Korri, Prado Luz-Nereida Perez, Langevin Anne-Marie, Grimes Allison C, Sugalski Aaron, Shah Shafqat, Assanasen Chatchawin, Lai Zhao, Zou Yi, Kurmashev Dias, Xu Lin, Xie Yang, Chen Yidong, Wang Xiaojing, Tomlinson Gail E, Skapek Stephen X, Houghton Peter J, Kurmasheva Raushan T, Zheng Siyuan
Abstract excerpt
Subcutaneous patient-derived xenografts (PDXs) are an important tool for childhood cancer research. Here, we describe a resource of 68 early passage PDXs established from 65 pediatric solid tumor patients. Through genomic profiling of paired PDXs and patient tumors (PTs), we observe low mutational similarity in about 30% of the PT/PDX pairs. Clonal analysis in these pairs show an aggressive PT minor subclone...
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