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Article

PCAT: an integrated portal for genomic and preclinical testing data of pediatric cancer patient-derived xenograft models.

Nucleic acids research - 8 Jan 2021

Yang Juechen, Li Qilin, Noureen Nighat, Fang Yanbing, Kurmasheva Raushan, Houghton Peter J, Wang Xiaojing, Zheng Siyuan

Abstract excerpt

Although cancer is the leading cause of disease-related mortality in children, the relative rarity of pediatric cancers poses a significant challenge for developing novel therapeutics to further improve prognosis. Patient-derived xenograft (PDX) models, which are usually developed from high-risk tumors, are a useful platform to study molecular driver events, identify biomarkers and prioritize therapeutic agents....

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Source

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Identifiers

PMID: 32810235
DOI: 10.1093/nar/gkaa698
PMCID: PMC7778893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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