Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV

Abstract excerpt

Eliciting broadly neutralizing antibodies (bnAbs) targeting envelope (Env) is a major goal of HIV vaccine development, but cross-clade breadth from immunization has only sporadically been observed. Recently, Xu et al (2018) elicited cross-reactive neutralizing antibody responses in a variety of animal models using immunogens based on the epitope of bnAb VRC34.01. The VRC34.01 antibody, which was elicited by natura...

Topics

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• Antibodies, Neutralizing
• env Gene Products, Human Immunodeficiency Virus
• Glycosylation and Glycoproteins Research
• HIV Antibodies
• HIV Research and Treatment
• Immune Evasion
• Monoclonal and Polyclonal Antibodies Research
• RNA and protein synthesis mechanisms

Identifiers and source

Literature Corpus work

221f4d62-7aa7-560c-a716-34d2904bede0

DOI

10.1101/307587