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Article

Essential roles of the ANKRD31-REC114 interaction in meiotic recombination and mouse spermatogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 21 Nov 2023

Xu Jiaqi, Li Tao, Kim Soonjoung, Boekhout Michiel, Keeney Scott

Abstract excerpt

Meiotic DNA double-strand breaks (DSBs) initiate homologous recombination and are crucial for ensuring proper chromosome segregation. In mice, ANKRD31 recently emerged as a regulator of DSB timing, number, and location, with a particularly important role in targeting DSBs to the pseudoautosomal regions (PARs) of sex chromosomes. ANKRD31 interacts with multiple proteins, including the conserved and essential...

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Identifiers

PMID: 37976262
DOI: 10.1073/pnas.2310951120
PMCID: PMC10666023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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