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Article

Homozygous mutations in REC114 cause female infertility characterised by multiple pronuclei formation and early embryonic arrest.

Journal of medical genetics - 1 Mar 2020

Wang Wenjing, Dong Jie, Chen Biaobang, Du Jing, Kuang Yanping, Sun Xiaoxi, Fu Jing, Li Bin, Mu Jian, Zhang Zhihua, Zhou Zhou, Lin Zhao, Wu Ling, Yan Zheng, Mao Xiaoyan, Li Qiaoli, He Lin, Wang Lei, Sang Qing

Abstract excerpt

BACKGROUND: Abnormal pronuclear formation during fertilisation and subsequent early embryonic arrest results in female infertility. In recent years, with the prevalence of assisted reproductive technology, a few genes have been identified that are involved in female infertility caused by abnormalities in oocyte development, fertilisation and embryonic development. However, the genetic factors responsible for...

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PMID: 31704776
DOI: 10.1136/jmedgenet-2019-106379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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