Article
The yeast PUF protein Puf5 has Pop2-independent roles in response to DNA replication stress.
PloS one - 14 May 2010
Traven Ana, Lo Tricia L, Lithgow Trevor, Heierhorst Jörg
Abstract excerpt
PUFs are RNA binding proteins that promote mRNA deadenylation and decay and inhibit translation. Yeast Puf5 is the prototype for studying PUF-dependent gene repression. Puf5 binds to the Pop2 subunit of the Ccr4-Pop2-NOT mRNA deadenylase, recruiting the deadenylase and associated translational repressors to mRNAs. Here we used yeast genetics to show that Puf5 has additional roles in vivo that do not require Pop2....
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