Article
A dynamic mutational landscape associated with an inter-regionally diverse immune response in malignant rhabdoid tumour.
The Journal of pathology - 1 Sept 2020
Yasui Hiroaki, Valind Anders, Karlsson Jenny, Pietras Christina, Jansson Caroline, Wille Joakim, Romerius Patrik, Backman Torbjörn, Gisselsson David
Abstract excerpt
Malignant rhabdoid tumour (MRT) is a childhood neoplasm of high malignancy characterised by biallelic mutation and/or loss of the epigenetic master regulator SMARCB1, accompanied by no or few other oncogenic drivers. In spite of their generally low mutational burden, an intratumoural T-cell response has been reported in a subset of MRTs, indicating that immune checkpoint inhibition may be considered a viable...
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